Systemic antibiotics for periodontitis
The Use of Systemic Antibiotics
in the Treatment of Periodontal Diseases.
THE DENTAL HEALTH
PAGE
Periodontal Horizons
Steven J. Spindler, D.D.S.
Periodontal Specialist
Paradigm Shift in the Management of Adult Periodontitis.
This issue will affect your office's perio program. In
1996, The American Academy of Periodontology puplished a "Position Paper"
entitled "Systemic Antibiotics in Periodontics" It was published in the
Journal of Periodontology and can be found in volume 67:831-838. The paper
urges restraint when prescribing antibiotics for periodontitis.
The article is full of supporting references and
has dramatically affected some of our treatment protocols. In this newsletter,
I will outline the major thrusts of the paper and then describe what we
are doing in light of this information.
The paper stresses the following
5 points:
1. Periodontal pockets almost never have only one
pathogen residing. Typical strains may include the following bacteria:
a. Actinobacillus actinomycetumcomitans
b. Porphyromonas gingivalis
c. Bacteriodes forcythus
d. Treponema denticola
e. Prevotella intermedia
f. Eubacterium nodatum [top]
2. Because of the pathogen mix, it is highly
unlikely that prescribing any one single antibiotic will be effective in
eradicating the flora.
3. The emerging resistance among
oral and medical pathogens to common antibiotics dictates a restrictive
and common sense conservative use of systemic antibiotic therapy.
4. Patients with gingivitis or stable
adult periodontitis usually respond well to mechanical periodontal therapy
alone and derive little or no additional benefit from antibiotic therapy.
5. Systemic antibiotic therapy for
periodontal therapy should be reserved to the following:
a. patients with medical problems requiring
antibiotic coverage.
b. juvenile periodontitis
c. patients with severe/acute periodontal
infections.
d. patients who are refractory and have continued
to breakdown in spite of thorough root debridement and excellent home care.
Previously, we have used systemic antibiotics,
most commonly Doxycycline, with patients in the maintenance phase of therapy
if they showed signs of returning inflammation. Additionally, we have used
Doxycycline in "pulsed dose deliveries" for our bone regenerative patients.
Wherever possible, we will avoid the
use of systemic antibiotics in the control of routine adult periodontitis
and rely instead upon stressing excellent oral hygiene and the use of topical
agents contained in rinses and pastes. I urge your practice to adopt the
same approach in your soft tissue and maintenance programs. [top]
Chemical Agents for Control of Plaque
and Gingivitis.
Literally hundreds of journal references
exist reporting the findings of studies which investigated the efficacies
of topical agents with respect to reductions in plaque and gingivitis.
Another position paper by The American Academy of Periodontology discusses
the research data on chemical agents. Some of the more important ones are
synopsed below.
Pre-Brushing Rinse (Plax)- multiple studies
have shown that there is no advantage with this product when compared to
placebos.
Fluorides- Multiple conflicting results have
been reported with regard to plaque levels and gingivitis therefore the
AAP suggests that fluorides be used only as an anticariogenic agent.
Sanguinarine(Viadent)- multiple research findings
are equivocal. Questions are raised about the long term safety of the extract.
We have not seen significant results in our patients on Viadent. [top]
Quarternary Ammonium Compounds (Scope and
Cepacol)- Multiple studies have shown plaque reductions of 25 to 35%, but
reports on gingivitis reductions are equivocal. We note some benefit with
these rinses, however alcohol content is up to 18%.
Triclosan- Just approved for use in USA. Data
shows significant reductions in plaque and gingivitis.
Chlorine dioxide (Oxyfresh)- Multiple studies
confirm excellent efficacy for halitosis. It is in phase 2 FDA clinical
trials for gingivitis efficacy. Some studies also reported pocket reductions
and significant improvements with bleeding on probing.Our office is participating
in this exciting research and the early results are promising. Oxyfresh
is mostly distributed by dental offices and if you are interested in offering
them to your patients, please Email me at 73302,554 @Compuserve.com. I
will be happy to work with you to effectively implement this into your
preventive and halitosis management programs.
Phenolics (Listerine)- Multiple studies confirm
35% reductions in plaque levels in the absense of any brushing or flossing
and significant improvements in gingival status are seen. This product
carries the ADA seal for plaque and gingivitis. The only disadvantages
are taste complaints and the 26% alcohol.
Chlorhexidine gluconate (Peridex or Perioguard)-
These are the most effective prescription products available to us for
reducing plaque and gingivitis. They both are FDA and ADA accepted. Multiple
studies confirm clinical benefits. We use these for short term assistance
during bone regeneration cases. Disadvantages include taste disturbances,
staining, increased calculus formation and it is inactivated by sodeium
lauryl sulfate, a majore ingedient in most dentifrices. The manufacturer's
advise waiting 30 minutes after brushing before rinsing and this has been
a compliance problem. [top]
Irrigation
Supragingival irrigation has long been
recognised as clinically beneficial especially when medicaments (Chlorhexidine,
Listerine or Oxyfresh) area diluted. Improvements are seen with microbiologic
and gingivitis studies. Gingival inflammation has been reduced up to 62%
in some studies. We are prescribing oral irrigators for any patient with
difficulty in interproximal plaque control. Again, this shift in philosophy
relates directly to our hesitancy in prescribing systemic antibiotics when
inflammation is returning. Reports on subgingival irrigation are conflicting
and thus it remains controversial, especially when done as a single, in
office delivery. This is largely due to the fact that the gingival crevicular
fluid washes the medicaments from the pockets too rapidly. Therefore "gels"
may be of greater benefit due to the "substantivity" during office use.
A chlorine dioxide gel (Oxyfresh) is being used in this manner. Other gels
are in development.
For information on where to obtain any
products contained in this page go to help on Selecting Oral
Care Products.
Hopefully this review of the current
literature describing the philosphy shift will help you in your perio programs.
[top]
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Periodontal Horizons
Steven J. Spindler, D.D.S.
Dr. Spindler provides continuing
education to dentists and dental hygienists on this subject and other topics
of interest in his specialty of periodontics. He also maintains a full
time private practice.
The information contained in this
website is for general informational purposes only and is not intended
to replace the advice and treatment you would receive by consulting with
a health care professional. By providing this service Dr. Spindler is simply
providing information to educate, you, the consumer.
Copyright © 1998
Steven J. Spindler
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